Musi waKubvumbi 15, 2022, kugadzirwa kwemutyairi weLecardipine hydrochloride main ring kwakapedzwa panguva imwe chete, uye iko zvino kugadzirwa kwe5Mt / mwedzi.
Chirungu Zita:Lercanidipine hydrochloride
Kemikari zita:1,4-Dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid 2--[(3,3-di phenylpropyl)methylamino]-l,l-dimethylethyl methyl ester hydrochloride.
Nhamba yeCAS: 132866-11-6
Application:Kurapa kweLecardipine hydrochloride mushonga, haizove nemhedzisiro yakaipa paglucose yeropa uye lipid mazinga, uye ine yakasimba antihypertensive effect.
Market tarisiro:
Kune vanopfuura 200 miriyoni varwere vane hypertension muChina, uye kune mamirioni gumi varwere vatsva vane hypertension gore rega rega, vazhinji vacho vasiri pasi pesimba, zvichikonzera kuwanda kwedambudziko rehypertension senge sitiroko, uye kufa kwepagore kuChina Pakati pevatatu. miriyoni varwere vane chirwere chemoyo, 50% vane hukama nehypertension, uye mutengo wepagore wekurapwa kwechirwere chemoyo ungangoita 309.8 bhiriyoni yuan.Chikonzero chekutadza kutonga hakusi chete kuti kuziva kwevarwere nezve hypertension uye matambudziko ayo kunoda kuvandudzwa, asiwo kuti varwere vazhinji vanofanirwa kutora mishonga yehupenyu hwese havateereri uye havagone kunwa mushonga mazuva ese Zvisinei, izvi zvinoratidza zvakare kuti Antihypertensive drug market ine mukana wekuwedzera.Kuenzaniswa nemishonga yakafanana, locarbodipine hydrochloride ine simba revascular selectivity.Yayo yakasarudzika lipophilic pfuma inoita kuti inonoke uye inogara yakasimba antihypertensive mhedzisiro Iyo atherogenic mhedzisiro, kunyanya yakakodzera kune varwere veBP vane atherosclerosis, ine yakakwirira yekiriniki yekushandisa kukosha uye yakakura musika tarisiro.
Pharmacological chiito:
Lecardipine chizvarwa chitsva che dihydropyridine calcium channel group hysteresis agent, ine yakasimba vascular selectivity, gentle effect, yakasimba antihypertensive effect, nguva yakareba yekuita, zvishoma zvakashata inotropic effect nezvimwe zvakadaro.In vitro zvidzidzo zvakaona kuti locarbodipine ine yakananga kuzorora mhedzisiro pavascular smooth tsandanyama, uye nekudaro ine yakasimba antihypertensive mhedzisiro mu vivo, asi ine zvishoma mhedzisiro pachiyero chemoyo uye kubuda kwemoyo.Nekuda kweiyo yakakura hydrophobic gene uye yakasimba lipid solubility, locarbodipine inokurumidza kugoverwa kumatishu uye nhengo mushure mekupinda mumuviri, ichinyatso sunga kune vascular smooth muscle cell membrane, uye kuburitsa zvishoma nezvishoma.Nokudaro, kunyange zvazvo serum yemishonga iyi ine nguva shomanana yekubvisa hafu-kukundikana, mhedzisiro yayo inogara kwenguva refu.
Nguva yekutumira: Kubvumbi-15-2022